![]() The patient received radiotherapy to the left breast, axilla and left supraclavicular fossa (40 Gray in fifteen fractions to the left breast and 50 Gray in twenty-five fractions to the left axilla and supraclavicular fossa) followed by gemcitabine and carboplatin chemotherapy with good response – staging computed tomography (CT) scan showed good response to chemotherapy with no significantly enlarged lymph nodes. ![]() Both radiological and ultrasonographic examinations were normal. The patient also complained of discomfort in the anterior neck. Planned surgery was therefore abandoned and the patient proceeded to weekly paclitaxel chemotherapy, receiving 6 cycles before progressing with new nodes in both supraclavicular fossae and left cervical lymph nodes and difficulty swallowing. In February 2006 she was found to have two enlarged right supraclavicular lymph nodes. The patient received 6 cycles of neoadjuvant epirubicin, cyclophosphamide and 5-fluorouracil (FEC) chemotherapy with good response. This case illustrates the importance of maintaining a high index of suspicion for metastatic disease in patients with invasive breast cancer who present with unusual symptoms and a careful search for metastatic sites.Ī 49 year old white woman was diagnosed in August 2005 with a grade 2 invasive mixed ductal and lobular carcinoma of the left breast (oestrogen receptor negative, progesterone receptor negative, HER2 receptor negative) with left supraclavicular lymphadenopathy, but no axillary lymphadenopathy. Repeat computed tomography scan and eventual oropharyngeal biopsy confirmed submucosal metastatic invasive ductal carcinoma, suggesting occult submucosal spread. The patient's symptoms preceded any associated radiological or endoscopic abnormalities by at least 9 months. We report the case of a 49 year old white woman with invasive ductal carcinoma with lobular differentiation who developed submucosal oropharyngeal metastases nearly two years after her original diagnosis after presenting with odynophagia and dysphagia. Lobular carcinoma is more likely to metastasise to the gastrointestinal tract. Studies have shown differing patterns of metastatic spread between ductal and lobular carcinoma. ![]() Metastatic breast cancer typically involves the lungs, bones, brain, and liver. Invasive ductal and lobular carcinomas represent 67.9% and 6.3% of breast carcinoma, respectively. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |